Home

Welcome to visit the manually curated database for differentially expressed genes after lncRNA knockdown or overexpression

Introduction:

Long noncoding RNAs (lncRNAs) have been emerged as critical regulators of gene expression at epigenetic, transcriptional and post-transcriptional level, yet what genes are regulated by lncRNAs remains to be characterized. To assess the effects of a specific lncRNA on gene expression, increasing researchers profiled the genome-wide or individual gene expression level changes after knocking down or overexpressing the lncRNA. However, no online repository is currently available to collect these differentially expressed genes regulated by lncRNAs.

To make it convenient for researchers to know what genes are regulated by a lncRNA or which lncRNAs regulate a given gene of interest, we develop this database to provide a comprehensive resource of differentially expressed genes after lncRNA knockdown or overexpression.

In our database system, target genes of a lncRNA are defined as the differentially expressed genes after knocking down or overexpressing the lncRNA. By reviewing all published lncRNA papers, we manually curated the differentially expressed target genes confirmed by qRT-PCR or western blot, and identified all the differential target genes from the microarray or RNA-seq data.

Currently, users can
• obtain the target genes regulated by a lncRNA by searching the lncRNA gene ID or symbol
• obtain the regulatory lncRNAs of a specific target gene by searching the target gene ID or symbol.
• download all manually curated lncRNA-target association data.
• submit information on new lncRNA knockdown and overexpression experiments to the LncRNA2Target database.

Statistics:

LncRNA knockdown or overexpression experiments followed by qRT-PCR or western blot to identify differentially expressed target genes:

No. of lncRNAs No. of target genes No. of lncRNA-target associations
Human 68 216 278
Mouse 26 95 118

LncRNA knockdown or overexpression experiments followed by microarray or RNA-seq to identify differentially expressed target genes:

No. of lncRNAs No. of target genes No. of lncRNA-target associations
Human 14 11,389 26,133
Mouse 109 14,667 67,034

Release & Version Information:

Aug 2, 2014, the LncRNA2Target database v1.2 was released.

Contact:

Yadong Wang, professor
Dean of School of Computer Science and Technology
Director of Center for Biomedical Informatics
Harbin Institute of Technology, Harbin 150001, China
Mail: ydwang@hit.edu.cn